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pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects.
Albuquerque, Lindomar J C; Sincari, Vladimir; Jäger, Alessandro; Kucka, Jan; Humajova, Jana; Pankrac, Jan; Paral, Petr; Heizer, Tomas; Janouskova, Olga; Davidovich, Irina; Talmon, Yeshayahu; Pouckova, Pavla; Stepánek, Petr; Sefc, Ludek; Hruby, Martin; Giacomelli, Fernando C; Jäger, Eliézer.
Affiliation
  • Albuquerque LJC; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André 09210-580, Brazil. Electronic address: lindomar.albuquerque
  • Sincari V; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Jäger A; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Kucka J; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Humajova J; Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovska, 1, 120 00 Prague, Czech Republic.
  • Pankrac J; Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, 120 00, Czech Republic.
  • Paral P; Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, 120 00, Czech Republic.
  • Heizer T; Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, 120 00, Czech Republic.
  • Janouskova O; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Davidovich I; Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology, Haifa 3200003, Israel.
  • Talmon Y; Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology, Haifa 3200003, Israel.
  • Pouckova P; Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovska, 1, 120 00 Prague, Czech Republic.
  • Stepánek P; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Sefc L; Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, Prague 2, 120 00, Czech Republic.
  • Hruby M; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic.
  • Giacomelli FC; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André 09210-580, Brazil.
  • Jäger E; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic. Electronic address: jager@imc.cas.cz.
J Control Release ; 332: 529-538, 2021 04 10.
Article in En | MEDLINE | ID: mdl-33716094
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Neoplasms Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2021 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Neoplasms Limits: Animals Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2021 Type: Article