Molecular modeling provides insights into the loading of sialic acid-containing antigens onto CRM<sub>197</sub>: the role of chain flexibility in conjugation efficiency and glycoconjugate architecture.

Kuttel, Michelle M; Berti, Francesco; Ravenscroft, Neil

Molecular modeling provides insights into the loading of sialic acid-containing antigens onto CRM₁₉₇: the role of chain flexibility in conjugation efficiency and glycoconjugate architecture.

Kuttel, Michelle M; Berti, Francesco; Ravenscroft, Neil.

Affiliation

Kuttel MM; Department of Computer Science, University of Cape Town, 7701, Cape Town, South Africa.
Berti F; Technical Research & Development, GSK Vaccines S.r.l, Via Fiorentina 1, 53100, Siena, Italy.
Ravenscroft N; Department of Chemistry, University of Cape Town, 7701, Cape Town, South Africa. neil.ravenscroft@uct.ac.za.

Glycoconj J ; 38(4): 411-419, 2021 08.

Article in En | MEDLINE | ID: mdl-33721150

Subject(s)

Antigens, Bacterial/chemistry; Bacterial Proteins/chemistry; Meningococcal Vaccines/chemistry; Molecular Dynamics Simulation; N-Acetylneuraminic Acid/chemistry; Humans; Meningococcal Vaccines/immunology

Key words

Antigen conformation; Capsular polysaccharide; Conjugation efficiency; Glycoconjugate structure; Molecular modeling; Neisseria meningitidis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / N-Acetylneuraminic Acid / Meningococcal Vaccines / Molecular Dynamics Simulation / Antigens, Bacterial Type of study: Prognostic_studies Limits: Humans Language: En Journal: Glycoconj J Journal subject: BIOQUIMICA / METABOLISMO Year: 2021 Type: Article Affiliation country: South Africa

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