Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation.

Bai, Yu-Ting; Xiao, Feng-Jun; Wang, Hua; Ge, Ri-Li; Wang, Li-Sheng

Bai, Yu-Ting; Xiao, Feng-Jun; Wang, Hua; Ge, Ri-Li; Wang, Li-Sheng.

Affiliation

Bai YT; Qinghai Provincial People's Hospital, Xining, 810001, PR China.
Xiao FJ; Research Center for High Altitude Medicine, Qinghai University, Xining, 810001, PR China.
Wang H; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
Ge RL; Beijing Institute of Radiation Medicine, Beijing, 100850, PR China.
Wang LS; Research Center for High Altitude Medicine, Qinghai University, Xining, 810001, PR China.

Int J Med Sci ; 18(7): 1618-1627, 2021.

Article in En | MEDLINE | ID: mdl-33746578

Subject(s)

Cell Hypoxia/genetics; Cysteine Endopeptidases/metabolism; Ferroptosis/genetics; Myocytes, Cardiac/pathology; Animals; Cell Movement/drug effects; Cell Movement/genetics; Cell Proliferation/drug effects; Cell Proliferation/genetics; Coenzyme A Ligases/metabolism; Cysteine Endopeptidases/genetics; Ferroptosis/drug effects; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Myocardial Ischemia/pathology; Myocytes, Cardiac/drug effects; Piperazines/pharmacology; Rats; Signal Transduction/genetics; Sumoylation/genetics; Up-Regulation

Key words

Ferroptosis; Hypoxia; SENP1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Cell Hypoxia / Myocytes, Cardiac / Ferroptosis Limits: Animals / Humans Language: En Journal: Int J Med Sci Journal subject: MEDICINA Year: 2021 Type: Article

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