A Randomized Trial of Tenapanor and Phosphate Binders as a Dual-Mechanism Treatment for Hyperphosphatemia in Patients on Maintenance Dialysis (AMPLIFY).

Pergola, Pablo E; Rosenbaum, David P; Yang, Yang; Chertow, Glenn M

Pergola, Pablo E; Rosenbaum, David P; Yang, Yang; Chertow, Glenn M.

Affiliation

Pergola PE; Renal Associates, P.A., San Antonio, Texas.
Rosenbaum DP; Ardelyx, Inc., Fremont, California.
Yang Y; Ardelyx, Inc., Fremont, California.
Chertow GM; Division of Nephrology, Stanford University School of Medicine, Stanford, California.

J Am Soc Nephrol ; 32(6): 1465-1473, 2021 06 01.

Article in En | MEDLINE | ID: mdl-33766811

Subject(s)

Chelating Agents/therapeutic use; Hyperphosphatemia/drug therapy; Isoquinolines/therapeutic use; Renal Dialysis; Sulfonamides/therapeutic use; Adult; Aged; Chelating Agents/adverse effects; Diarrhea/chemically induced; Double-Blind Method; Drug Therapy, Combination/adverse effects; Female; Fibroblast Growth Factor-23; Humans; Hyperphosphatemia/blood; Isoquinolines/adverse effects; Male; Middle Aged; Phosphorus/blood; Renal Insufficiency, Chronic/therapy; Sevelamer/therapeutic use; Sodium-Hydrogen Exchanger 3/antagonists & inhibitors; Sulfonamides/adverse effects

Key words

FGF23; NHE3 dialysis; hyperphosphatemia; phosphate binders; phosphate uptake; phosphorus; tenapanor

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Chelating Agents / Renal Dialysis / Hyperphosphatemia / Isoquinolines Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2021 Type: Article

Fulltext

XML

PubMed Links

Search on Google