Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models.

Xue, Yaping; Chidiac, Celeste; Herault, Yann; Gaveriaux-Ruff, Claire

Xue, Yaping; Chidiac, Celeste; Herault, Yann; Gaveriaux-Ruff, Claire.

Affiliation

Xue Y; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) Translational Medicine and Neurogenetics Department, Illkirch, France.
Chidiac C; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) Translational Medicine and Neurogenetics Department, Illkirch, France.
Herault Y; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) Translational Medicine and Neurogenetics Department, Illkirch, France. Electronic address: herault@igbmc.fr.
Gaveriaux-Ruff C; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) Translational Medicine and Neurogenetics Department, Illkirch, France.

Neurosci Lett ; 753: 135844, 2021 05 14.

Article in En | MEDLINE | ID: mdl-33775738

Subject(s)

Analgesics/pharmacology; NAV1.7 Voltage-Gated Sodium Channel/genetics; NAV1.8 Voltage-Gated Sodium Channel/genetics; Pain/genetics; Small Fiber Neuropathy/complications; Analgesics/therapeutic use; Animals; Disease Models, Animal; Gain of Function Mutation; Humans; Loss of Function Mutation; Mice; Mice, Knockout; NAV1.7 Voltage-Gated Sodium Channel/metabolism; NAV1.8 Voltage-Gated Sodium Channel/metabolism; Nociception/drug effects; Pain/drug therapy; Rats; Rats, Transgenic; Small Fiber Neuropathy/drug therapy; Small Fiber Neuropathy/genetics; Voltage-Gated Sodium Channel Agonists/pharmacology; Voltage-Gated Sodium Channel Agonists/therapeutic use; Voltage-Gated Sodium Channel Blockers/pharmacology; Voltage-Gated Sodium Channel Blockers/therapeutic use

Key words

Knockout; Mutant; Nav1.7; Nav1.8; Neuropathic pain; Pain behavior; Rodent model; SCN10A; SCN9A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / NAV1.7 Voltage-Gated Sodium Channel / NAV1.8 Voltage-Gated Sodium Channel / Small Fiber Neuropathy / Analgesics Limits: Animals / Humans Language: En Journal: Neurosci Lett Year: 2021 Type: Article Affiliation country: France

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