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Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy.
Wang, J Y; Xiu, J; Baca, Y; Arai, H; Battaglin, F; Kawanishi, N; Soni, S; Zhang, W; Millstein, J; Shields, A F; Grothey, A; Weinberg, B A; Marshall, J L; Lou, E; Khushman, M; Sohal, D P S; Hall, M J; Oberley, M; Spetzler, D; Shen, L; Korn, W M; Lenz, H J.
Affiliation
  • Wang JY; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University
  • Xiu J; Caris Life Sciences, Phoenix, USA.
  • Baca Y; Caris Life Sciences, Phoenix, USA.
  • Arai H; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Battaglin F; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Kawanishi N; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Soni S; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Zhang W; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Millstein J; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Shields AF; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, USA.
  • Grothey A; GI Cancer Research, West Cancer Center and Research Institute, Germantown, USA.
  • Weinberg BA; Division of Hematology and Oncology, Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
  • Marshall JL; Division of Hematology and Oncology, Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.
  • Lou E; Division of Hematology, Oncology and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
  • Khushman M; Department of Interdisciplinary Clinical Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, USA.
  • Sohal DPS; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, USA.
  • Hall MJ; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, USA.
  • Oberley M; Caris Life Sciences, Phoenix, USA.
  • Spetzler D; Caris Life Sciences, Phoenix, USA.
  • Shen L; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
  • Korn WM; Caris Life Sciences, Phoenix, USA.
  • Lenz HJ; Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address: Lenz@usc.edu.
Ann Oncol ; 32(7): 906-916, 2021 07.
Article in En | MEDLINE | ID: mdl-33798656

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / B7-H1 Antigen / Immunotherapy Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / B7-H1 Antigen / Immunotherapy Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article