Long-term functional alterations following prenatal GLP-1R activation.
Neurotoxicol Teratol
; 87: 106984, 2021.
Article
in En
| MEDLINE
| ID: mdl-33864929
ABSTRACT
Evidence supporting the use of glucagon-like peptide-1 (GLP-1) analogues to pharmacologically treat disorders beyond type 2 diabetes and obesity is increasing. However, little is known about how activation of the GLP-1 receptor (GLP-1R) during pregnancy affects maternal and offspring outcomes. We treated female C57Bl/6 J mice prior to conception and throughout gestation with a long-lasting GLP-1R agonist, Exendin-4. While GLP-1R activation has significant effects on food and drug reward, depression, locomotor activity, and cognition in adults, we found few changes in these domains in exendin-4-exposed offspring. Repeated injections of Exendin-4 had minimal effects on the dams and may have enhanced maternal care. Offspring exposed to the drug weighed significantly more than their control counterparts during the preweaning period and demonstrated alterations in anxiety-like outcomes, which indicate a developmental role for GLP-1R modulation in the stress response that may be sex-specific.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Time
/
Glucagon-Like Peptide 1
/
Glucagon-Like Peptide-1 Receptor
/
Exenatide
Limits:
Animals
Language:
En
Journal:
Neurotoxicol Teratol
Journal subject:
NEUROLOGIA
/
TOXICOLOGIA
Year:
2021
Type:
Article
Affiliation country:
United States