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Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.
Suwala, Abigail K; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L N; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D; Chotard, Guillaume; Bjergvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M; Reuss, David E; Wick, Wolfgang; von Deimling, Andreas; Jones, David T W; Sahm, Felix.
Affiliation
  • Suwala AK; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Stichel D; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Schrimpf D; Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco, San Francisco, CA, USA.
  • Maas SLN; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sill M; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Dohmen H; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Banan R; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Reinhardt A; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sievers P; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Hinz F; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Blattner-Johnson M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Hartmann C; Institute of Neuropathology, University of Giessen, Giessen, Germany.
  • Schweizer L; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Boldt HB; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Kristensen BW; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Schittenhelm J; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Wood MD; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Chotard G; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Bjergvig R; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Das A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Tabori U; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hasselblatt M; Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany.
  • Korshunov A; Department of Neuropathology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Abdullaev Z; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Quezado M; Department of Pathology, Odense University Hospital, Odense, Denmark.
  • Aldape K; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Harter PN; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Snuderl M; Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.
  • Hench J; Institute of Pathology and Neuropathology, Department of Neuropathology, University Hospital Tübingen, Tübingen, Germany.
  • Frank S; Department of Pathology, Oregon Health and Science University, Portland, OR, USA.
  • Acker T; Department of Pathology, Hospital Center University of Bordeaux, Bordeaux, France.
  • Brandner S; Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Winkler F; Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
  • Wesseling P; Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
  • Pfister SM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.
  • Reuss DE; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada.
  • Wick W; Institute of Neuropathology, University Hospital Münster, Munster, Germany.
  • von Deimling A; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
  • Jones DTW; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Sahm F; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Acta Neuropathol ; 142(1): 179-189, 2021 07.
Article in En | MEDLINE | ID: mdl-33876327
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Tumor Suppressor Protein p53 / Neuroectodermal Tumors, Primitive / Glioblastoma / DNA Methylation / Ubiquitin-Protein Ligases / PTEN Phosphohydrolase / Retinoblastoma Binding Proteins Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Acta Neuropathol Year: 2021 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Tumor Suppressor Protein p53 / Neuroectodermal Tumors, Primitive / Glioblastoma / DNA Methylation / Ubiquitin-Protein Ligases / PTEN Phosphohydrolase / Retinoblastoma Binding Proteins Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Acta Neuropathol Year: 2021 Type: Article Affiliation country: Germany