Mutated Measles Virus Matrix and Fusion Protein Influence Viral Titer In Vitro and Neuro-Invasion in Lewis Rat Brain Slice Cultures.

Busch, Johannes; Chey, Soroth; Sieg, Michael; Vahlenkamp, Thomas W; Liebert, Uwe G

Busch, Johannes; Chey, Soroth; Sieg, Michael; Vahlenkamp, Thomas W; Liebert, Uwe G.

Affiliation

Busch J; Institute of Virology, University Hospital Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
Chey S; Faculty of Veterinary Medicine, Institute of Virology, Leipzig University, An den Tierkliniken 29, 04103 Leipzig, Germany.
Sieg M; Institute of Virology, University Hospital Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
Vahlenkamp TW; Faculty of Veterinary Medicine, Institute of Virology, Leipzig University, An den Tierkliniken 29, 04103 Leipzig, Germany.
Liebert UG; Faculty of Veterinary Medicine, Institute of Virology, Leipzig University, An den Tierkliniken 29, 04103 Leipzig, Germany.

Viruses ; 13(4)2021 04 01.

Article in En | MEDLINE | ID: mdl-33916225

Subject(s)

Brain/virology; Measles virus/genetics; Mutation; Neurons/virology; Viral Proteins/genetics; Viral Tropism/genetics; Animals; Chlorocebus aethiops; HEK293 Cells; Humans; In Vitro Techniques; Measles/virology; Measles virus/pathogenicity; Measles virus/physiology; Rats, Inbred Lew; Reverse Genetics; Signaling Lymphocytic Activation Molecule Family Member 1/genetics; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism; Vero Cells; Viral Fusion Proteins/genetics

Key words

brain slice culture; measles virus; mutagenesis; neurotropism; reverse genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Brain / Viral Tropism / Measles virus / Mutation / Neurons Limits: Animals / Humans Language: En Journal: Viruses Year: 2021 Type: Article Affiliation country: Germany

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