RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy.

Herrmann, Jonas; Schmidt, Helena; Nitschke, Katja; Weis, Cleo-Aron; Nuhn, Philipp; von Hardenberg, Jost; Michel, Maurice Stephan; Erben, Philipp; Worst, Thomas Stefan

Herrmann, Jonas; Schmidt, Helena; Nitschke, Katja; Weis, Cleo-Aron; Nuhn, Philipp; von Hardenberg, Jost; Michel, Maurice Stephan; Erben, Philipp; Worst, Thomas Stefan.

Affiliation

Herrmann J; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Schmidt H; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Nitschke K; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Weis CA; Institute for Pathology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Nuhn P; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
von Hardenberg J; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Michel MS; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Erben P; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Worst TS; Department of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.

Int J Mol Sci ; 22(8)2021 Apr 18.

Article in En | MEDLINE | ID: mdl-33919527

Subject(s)

Antineoplastic Agents/therapeutic use; Cisplatin/therapeutic use; Urinary Bladder Neoplasms/drug therapy; Adult; Aged; Aged, 80 and over; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; BRCA2 Protein/genetics; BRCA2 Protein/metabolism; Biomarkers, Tumor; Chemotherapy, Adjuvant; DNA Damage/drug effects; DNA Damage/genetics; Female; Forkhead Box Protein M1/genetics; Forkhead Box Protein M1/metabolism; Humans; Male; Middle Aged; Neoplasm Invasiveness/prevention & control; Urinary Bladder Neoplasms/genetics

Key words

BCL2; BRCA1; BRCA2; DNA-damage response; ERCC2; ERCC6; FOXM1; RAD50; RAD51; RAD52; adjuvant chemotherapy; cisplatin; muscle-invasive bladder cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Cisplatin / Antineoplastic Agents Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Germany

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