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Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
Komulainen, Emilia; Badman, Jack; Rey, Stephanie; Rulten, Stuart; Ju, Limei; Fennell, Kate; Kalasova, Ilona; Ilievova, Kristyna; McKinnon, Peter J; Hanzlikova, Hana; Staras, Kevin; Caldecott, Keith W.
Affiliation
  • Komulainen E; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Badman J; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Rey S; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
  • Rulten S; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
  • Ju L; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Fennell K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Kalasova I; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
  • Ilievova K; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
  • McKinnon PJ; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
  • Hanzlikova H; Department of Genetics, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Staras K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  • Caldecott KW; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
EMBO Rep ; 22(5): e51851, 2021 05 05.
Article in En | MEDLINE | ID: mdl-33932076
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium / DNA-Binding Proteins Limits: Animals Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United kingdom
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium / DNA-Binding Proteins Limits: Animals Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United kingdom