Targeted dual inhibition of c-Met/VEGFR2 signalling by foretinib improves antitumour effects of nanoparticle paclitaxel in gastric cancer models.

Grojean, Meghan; Schwarz, Margaret A; Schwarz, Johann R; Hassan, Sazzad; von Holzen, Urs; Zhang, Changhua; Schwarz, Roderich E; Awasthi, Niranjan

Grojean, Meghan; Schwarz, Margaret A; Schwarz, Johann R; Hassan, Sazzad; von Holzen, Urs; Zhang, Changhua; Schwarz, Roderich E; Awasthi, Niranjan.

Affiliation

Grojean M; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
Schwarz MA; Department of Pediatrics, Indiana University School of Medicine, South Bend, IN, USA.
Schwarz JR; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.
Hassan S; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
von Holzen U; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
Zhang C; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.
Schwarz RE; Department of Surgery, Indiana University School of Medicine, South Bend, IN, USA.
Awasthi N; Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA.

J Cell Mol Med ; 25(11): 4950-4961, 2021 06.

Article in En | MEDLINE | ID: mdl-33939252

Subject(s)

Anilides/pharmacology; Drug Synergism; Nanoparticles/administration & dosage; Paclitaxel/pharmacology; Proto-Oncogene Proteins c-met/antagonists & inhibitors; Quinolines/pharmacology; Stomach Neoplasms/drug therapy; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis; Cell Proliferation; Drug Combinations; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles/chemistry; Prognosis; Stomach Neoplasms/genetics; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

c-Met; combination therapy; foretinib; gastric cancer; nab-paclitaxel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Stomach Neoplasms / Paclitaxel / Proto-Oncogene Proteins c-met / Vascular Endothelial Growth Factor Receptor-2 / Drug Synergism / Nanoparticles / Anilides Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United States

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