Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells.

Manoli, Sagar S; Kisor, Kyle; Webb, Bradley A; Barber, Diane L

Manoli, Sagar S; Kisor, Kyle; Webb, Bradley A; Barber, Diane L.

Affiliation

Manoli SS; Department of Cell and Tissue Biology, University of California, San Francisco, California.
Kisor K; Department of Cell and Tissue Biology, University of California, San Francisco, California.
Webb BA; Department of Biochemistry, West Virginia University, Morgantown, West Virginia.
Barber DL; Department of Cell and Tissue Biology, University of California, San Francisco, California.

Am J Physiol Cell Physiol ; 321(1): C147-C157, 2021 07 01.

Article in En | MEDLINE | ID: mdl-34038242

Subject(s)

Amiloride/analogs & derivatives; Epithelial Sodium Channel Blockers/pharmacology; Mitochondrial Dynamics/drug effects; Oxidative Phosphorylation/drug effects; Sodium-Hydrogen Exchanger 1/genetics; Amiloride/pharmacology; Cell Line; Cell Line, Tumor; Clone Cells; Epithelial Cells/cytology; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Gene Expression; Glycolysis/genetics; Humans; Hydrogen-Ion Concentration; Lactic Acid/metabolism; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Oxygen Consumption/drug effects; Phosphofructokinase-1/genetics; Phosphofructokinase-1/metabolism; Pyruvic Acid/metabolism; Sodium-Hydrogen Exchanger 1/antagonists & inhibitors; Sodium-Hydrogen Exchanger 1/metabolism

Key words

NHE1; cancer metabolism; intracellular pH; lactate; mitochondria; oxidative phosphorylation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Phosphorylation / Epithelial Sodium Channel Blockers / Mitochondrial Dynamics / Sodium-Hydrogen Exchanger 1 / Amiloride Type of study: Prognostic_studies Limits: Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2021 Type: Article

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