How Neural Crest Transcription Factors Contribute to Melanoma Heterogeneity, Cellular Plasticity, and Treatment Resistance.

Wessely, Anja; Steeb, Theresa; Berking, Carola; Heppt, Markus Vincent

Wessely, Anja; Steeb, Theresa; Berking, Carola; Heppt, Markus Vincent.

Affiliation

Wessely A; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Steeb T; Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), 91054 Erlangen, Germany.
Berking C; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Heppt MV; Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), 91054 Erlangen, Germany.

Int J Mol Sci ; 22(11)2021 May 28.

Article in En | MEDLINE | ID: mdl-34071193

Subject(s)

Cell Plasticity/physiology; Drug Resistance, Neoplasm/physiology; Melanoma/metabolism; Neural Crest/metabolism; Skin Neoplasms/metabolism; Acrylonitrile/analogs & derivatives; Acrylonitrile/pharmacology; Aniline Compounds/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Cell Differentiation; Cell Movement; Drug Resistance, Neoplasm/genetics; Forkhead Transcription Factors/genetics; Gene Expression Regulation, Neoplastic/drug effects; MSX1 Transcription Factor/genetics; Melanocytes/metabolism; Melanoma/drug therapy; Melanoma/pathology; Microphthalmia-Associated Transcription Factor/genetics; PAX3 Transcription Factor/genetics; Phenotype; Pyrimidinones/pharmacology; SOXE Transcription Factors/genetics; Skin Neoplasms/drug therapy; Skin Neoplasms/pathology

Key words

FOXD3; MITF; MSX1; PAX3; SOX10; cellular plasticity; melanoma; neural crest; phenotype switch

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Drug Resistance, Neoplasm / Cell Plasticity / Melanoma / Neural Crest Type of study: Prognostic_studies / Screening_studies Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Germany

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