The Evolution of Rag Gene Enhancers and Transcription Factor E and Id Proteins in the Adaptive Immune System.

Yoshikawa, Genki; Miyazaki, Kazuko; Ogata, Hiroyuki; Miyazaki, Masaki

Yoshikawa, Genki; Miyazaki, Kazuko; Ogata, Hiroyuki; Miyazaki, Masaki.

Affiliation

Yoshikawa G; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
Miyazaki K; Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Ogata H; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
Miyazaki M; Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Int J Mol Sci ; 22(11)2021 May 31.

Article in En | MEDLINE | ID: mdl-34072618

Subject(s)

Adaptive Immunity/genetics; Enhancer Elements, Genetic; Evolution, Molecular; Homeodomain Proteins/genetics; Transcription Factors/genetics; Animals; B-Lymphocytes/cytology; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Cell Differentiation/genetics; Cell Differentiation/immunology; Gene Expression Regulation; Humans; Regulatory Sequences, Nucleic Acid; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Transcription Factors/metabolism; V(D)J Recombination

Key words

E protein; Id protein; Rag1/2 gene enhancers; T and B cell development; adaptive immune system; bHLH transcription factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Enhancer Elements, Genetic / Homeodomain Proteins / Evolution, Molecular / Adaptive Immunity Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Japan

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