Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages.

Aurubin, C A; Knaack, D A; Sahoo, D; Tarakanova, V L

Aurubin, C A; Knaack, D A; Sahoo, D; Tarakanova, V L.

Affiliation

Aurubin CA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Knaack DA; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Sahoo D; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Tarakanova VL; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

J Virol ; 95(17): e0064921, 2021 08 10.

Article in En | MEDLINE | ID: mdl-34105999

Subject(s)

Cholesterol/biosynthesis; Gammaherpesvirinae/physiology; Herpesviridae Infections/prevention & control; Lipogenesis; Macrophages/metabolism; Receptors, LDL/metabolism; Virus Replication; Animals; Female; Herpesviridae Infections/pathology; Herpesviridae Infections/virology; Host-Pathogen Interactions; Interferon Type I/metabolism; Macrophages/pathology; Macrophages/virology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL/genetics; Signal Transduction

Key words

LDL receptor; cholesterol; gammaherpesvirus; interferons; lytic replication

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / Receptors, LDL / Cholesterol / Gammaherpesvirinae / Herpesviridae Infections / Lipogenesis / Macrophages Limits: Animals Language: En Journal: J Virol Year: 2021 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google