Exploring the molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 using molecular dynamics simulation and free energy calculation.

Sun, Han; Chen, Wei; Chen, Lin; Zheng, Wenqing

Sun, Han; Chen, Wei; Chen, Lin; Zheng, Wenqing.

Affiliation

Sun H; College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, China.
Chen W; College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, China.
Chen L; College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, China.

J Comput Chem ; 42(23): 1670-1680, 2021 09 05.

Article in En | MEDLINE | ID: mdl-34109652

Subject(s)

DNA-Binding Proteins/genetics; Molecular Dynamics Simulation; RNA/genetics; Thermodynamics; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Humans; RNA/chemistry; RNA/metabolism

Key words

TDP-43; free energy calculation; molecular dynamics simulation; mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thermodynamics / RNA / DNA-Binding Proteins / Molecular Dynamics Simulation Limits: Humans Language: En Journal: J Comput Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: China

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