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Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16.
Minasov, George; Rosas-Lemus, Monica; Shuvalova, Ludmilla; Inniss, Nicole L; Brunzelle, Joseph S; Daczkowski, Courtney M; Hoover, Paul; Mesecar, Andrew D; Satchell, Karla J F.
Affiliation
  • Minasov G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.
  • Rosas-Lemus M; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Shuvalova L; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.
  • Inniss NL; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Brunzelle JS; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.
  • Daczkowski CM; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Hoover P; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine,,Chicago, IL 60611, USA.
  • Mesecar AD; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Satchell KJF; Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, IL 60439, USA.
Sci Signal ; 14(689)2021 06 29.
Article in En | MEDLINE | ID: mdl-34131072
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Caps / RNA, Viral / Viral Nonstructural Proteins / SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2021 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Caps / RNA, Viral / Viral Nonstructural Proteins / SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2021 Type: Article Affiliation country: United States