Tocilizumab-associated posterior reversible encephalopathy syndrome in giant-cell arteritis - case report.
BMC Neurol
; 21(1): 228, 2021 Jun 22.
Article
in En
| MEDLINE
| ID: mdl-34157987
ABSTRACT
BACKROUND We describe one of the first cases of a Posterior reversible encephalopathy syndrome (PRES) under tocilizumab as treatment of Giant cell arteritis (GCA). CASE PRESENTATION A 65-year-old female with known GCA and treatment with Tocilizumab (TCZ) developed a convulsive epileptic seizure for the first time. MRI was suggestive of PRES and an associated left sided occipital hemorrhage. Extensive high blood pressure values were not detected. The patient recovered within a week and no further seizures occurred under anticonvulsive medication. CONCLUSION:
PRES during the treatment with Tocilizumab hasn't been described in GCA so far. There are single reports of an association between TCZ and PRES in other entities. Thus, a link between interleukin-6 and the integrity of the vasculature could be considered. The clinical consequence should be a stringent blood pressure monitoring in the ambulant setting of patients receiving TCZ.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Giant Cell Arteritis
/
Posterior Leukoencephalopathy Syndrome
/
Antibodies, Monoclonal, Humanized
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
BMC Neurol
Journal subject:
NEUROLOGIA
Year:
2021
Type:
Article
Affiliation country:
Germany