Vascular effects of disrupting endothelial mTORC1 signaling in obesity.

Reho, John J; Guo, Deng-Fu; Beyer, Andreas M; Wegman-Points, Lauren; Pierce, Gary L; Rahmouni, Kamal

Reho, John J; Guo, Deng-Fu; Beyer, Andreas M; Wegman-Points, Lauren; Pierce, Gary L; Rahmouni, Kamal.

Affiliation

Reho JJ; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa.
Guo DF; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa.
Beyer AM; Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa.
Wegman-Points L; Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Pierce GL; Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa.
Rahmouni K; Department of Internal Medicine, University of Iowa, Iowa City, Iowa.

Am J Physiol Regul Integr Comp Physiol ; 321(2): R228-R237, 2021 08 01.

Article in En | MEDLINE | ID: mdl-34189960

Subject(s)

Endothelium, Vascular/enzymology; Mechanistic Target of Rapamycin Complex 1/deficiency; Obesity/prevention & control; Subcutaneous Fat/blood supply; Vasodilation; Animals; Aorta, Thoracic/enzymology; Aorta, Thoracic/physiopathology; Case-Control Studies; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Endothelium, Vascular/physiopathology; Humans; Male; Mechanistic Target of Rapamycin Complex 1/genetics; Mesenteric Arteries/enzymology; Mesenteric Arteries/physiopathology; Mice, Inbred C57BL; Mice, Knockout; Obesity/enzymology; Obesity/genetics; Obesity/physiopathology; Regulatory-Associated Protein of mTOR/deficiency; Regulatory-Associated Protein of mTOR/genetics; Signal Transduction

Key words

endothelial dysfunction; high-fat diet; mTORC1; obesity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Endothelium, Vascular / Subcutaneous Fat / Mechanistic Target of Rapamycin Complex 1 / Obesity Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: FISIOLOGIA Year: 2021 Type: Article

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