The Prognostic Ability of RAS Pathway-Related Gene Mutations in Patients with Myeloid Neoplasms Treated with Hypomethylating Agents.

Park, Hee Sue; Son, Bo Ra; Shin, Kyeong Seob; Byeon, Seonggyu; Kim, Hee Kyung; Yang, Yaewon; Jeong, Yusook; Han, Hye Sook; Lee, Ki Hyeong; Kwon, Jihyun

Park, Hee Sue; Son, Bo Ra; Shin, Kyeong Seob; Byeon, Seonggyu; Kim, Hee Kyung; Yang, Yaewon; Jeong, Yusook; Han, Hye Sook; Lee, Ki Hyeong; Kwon, Jihyun.

Affiliation

Park HS; Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Son BR; Laboratory Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Shin KS; Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Byeon S; Laboratory Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Kim HK; Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Yang Y; Laboratory Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Jeong Y; Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Han HS; Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Lee KH; Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Kwon J; Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Acta Haematol ; 144(6): 649-659, 2021.

Article in En | MEDLINE | ID: mdl-34233332

Subject(s)

Leukemia, Myeloid, Acute/genetics; Leukemia, Myelomonocytic, Chronic/genetics; Myelodysplastic Syndromes/genetics; Proto-Oncogene Proteins p21(ras)/genetics; Signal Transduction/genetics; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic/therapeutic use; Decitabine/therapeutic use; Female; Humans; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/mortality; Leukemia, Myelomonocytic, Chronic/drug therapy; Leukemia, Myelomonocytic, Chronic/mortality; Male; Middle Aged; Mutation; Myelodysplastic Syndromes/drug therapy; Myelodysplastic Syndromes/mortality; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-kit/genetics; Survival Rate; Tumor Suppressor Protein p53/genetics; fms-Like Tyrosine Kinase 3/genetics

Key words

Acute myeloid leukemia; Genetic mutation; Hypomethylating agent; Myelodysplastic syndrome; Next-generation sequencing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / Leukemia, Myelomonocytic, Chronic / Leukemia, Myeloid, Acute / Signal Transduction / Proto-Oncogene Proteins p21(ras) Type of study: Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Acta Haematol Year: 2021 Type: Article

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