A new thinking: extended application of genomic selection to screen multiomics data for development of novel hypoxia-immune biomarkers and target therapy of clear cell renal cell carcinoma.

Gui, Cheng-Peng; Wei, Jin-Huan; Chen, Yu-Hang; Fu, Liang-Min; Tang, Yi-Ming; Cao, Jia-Zheng; Chen, Wei; Luo, Jun-Hang

Gui, Cheng-Peng; Wei, Jin-Huan; Chen, Yu-Hang; Fu, Liang-Min; Tang, Yi-Ming; Cao, Jia-Zheng; Chen, Wei; Luo, Jun-Hang.

Affiliation

Gui CP; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Wei JH; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen YH; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Fu LM; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Tang YM; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Cao JZ; Affiliated Jiangmen Hospital, Sun Yat-sen University, Jiangmen, Guangdong, China.
Chen W; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Luo JH; First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Brief Bioinform ; 22(6)2021 11 05.

Article in En | MEDLINE | ID: mdl-34237133

Subject(s)

Biomarkers, Tumor; Carcinoma, Renal Cell/etiology; Carcinoma, Renal Cell/metabolism; Disease Susceptibility; Kidney Neoplasms/etiology; Kidney Neoplasms/metabolism; Aged; Carcinoma, Renal Cell/diagnosis; Carcinoma, Renal Cell/therapy; DNA Methylation; Disease Susceptibility/immunology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics; Humans; Hypoxia/genetics; Hypoxia/metabolism; Immunophenotyping; Kaplan-Meier Estimate; Kidney Neoplasms/diagnosis; Kidney Neoplasms/therapy; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Staging; Precision Medicine; Prognosis; ROC Curve; Transcriptome; Tumor Microenvironment

Key words

clear cell renal cell carcinoma; hypoxia; immune; multiomics data analysis; precision medicine; prognosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Biomarkers, Tumor / Disease Susceptibility / Kidney Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Brief Bioinform Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2021 Type: Article Affiliation country: China

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