Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma.

Zhang, Lishun; Yang, Zichao; Sang, Huiting; Jiang, Ying; Zhou, Mingfeng; Huang, Chuan; Huang, Chunhui; Wu, Xiaoyun; Zhang, Tingting; Zhang, Xingmei; Wan, Shanhe; Zhang, Jiajie

Zhang, Lishun; Yang, Zichao; Sang, Huiting; Jiang, Ying; Zhou, Mingfeng; Huang, Chuan; Huang, Chunhui; Wu, Xiaoyun; Zhang, Tingting; Zhang, Xingmei; Wan, Shanhe; Zhang, Jiajie.

Affiliation

Zhang L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Yang Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Sang H; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Jiang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhou M; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Huang C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Wu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang X; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, PR China.
Wan S; Department of Neurobiology, Guangdong Province Key Laboratory of Psychiatric Disorders, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.

J Enzyme Inhib Med Chem ; 36(1): 1541-1552, 2021 Dec.

Article in En | MEDLINE | ID: mdl-34238111

Subject(s)

Antineoplastic Agents/pharmacology; Brain Neoplasms/drug therapy; Glioblastoma/drug therapy; Imidazoles/pharmacology; Protein Kinase Inhibitors/pharmacology; Quinolones/pharmacology; src-Family Kinases/antagonists & inhibitors; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma/metabolism; Glioblastoma/pathology; Humans; Imidazoles/chemical synthesis; Imidazoles/chemistry; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/chemistry; Quinolones/chemical synthesis; Quinolones/chemistry; Structure-Activity Relationship; src-Family Kinases/metabolism

Key words

Glioblastoma; Src family kinase; imidazo[4,5-c]pyridin-2-one; kinase inhibitor; molecular simulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Quinolones / Src-Family Kinases / Protein Kinase Inhibitors / Imidazoles / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article

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