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Cytokine profiles in children with acute intussusception in South Africa.
Bessey, Theresa K; Parashar, Umesh D; Tate, Jacqueline E; Madhi, Shabir A; Jiang, Baoming; Groome, Michelle J.
Affiliation
  • Bessey TK; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
  • Parashar UD; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
  • Tate JE; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
  • Madhi SA; South African Medical Research Council/Wits Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Jiang B; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. Electronic address: bxj4@cdc.gov.
  • Groome MJ; South African Medical Research Council/Wits Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Cytokine ; 146: 155639, 2021 10.
Article in En | MEDLINE | ID: mdl-34284276
ABSTRACT
Serum specimens of children hospitalized with acute intussusception (IS; n = 407) were analyzed for various pro- and anti-inflammatory cytokines to identify host markers specifically for IS compared to other surgical conditions (n = 235) or acute gastroenteritis (AGE; n = 68) in a cross-sectional study design. We showed that children with IS had elevated levels of pro-inflammatory cytokines IFN-γ, TNF-α, MIP-1ß, IL-1ß, IL-2, IL-6, IL-7, IL-8, and IL-17 as well as anti-inflammatory cytokines IL-1RA, IL-4, IL-5, and IL-13 compared to those admitted with surgical conditions or AGE symptoms, indicating these cytokines as markers for IS. In addition, we showed an increase in C-reactive protein (CRP) levels in children with IS. This study is the first to show a broad cytokine profile and identify cytokine markers in children with IS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Intussusception Type of study: Observational_studies Limits: Child / Female / Humans / Infant / Male / Newborn Country/Region as subject: Africa Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Intussusception Type of study: Observational_studies Limits: Child / Female / Humans / Infant / Male / Newborn Country/Region as subject: Africa Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: United States