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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
Tummino, Tia A; Rezelj, Veronica V; Fischer, Benoit; Fischer, Audrey; O'Meara, Matthew J; Monel, Blandine; Vallet, Thomas; White, Kris M; Zhang, Ziyang; Alon, Assaf; Schadt, Heiko; O'Donnell, Henry R; Lyu, Jiankun; Rosales, Romel; McGovern, Briana L; Rathnasinghe, Raveen; Jangra, Sonia; Schotsaert, Michael; Galarneau, Jean-René; Krogan, Nevan J; Urban, Laszlo; Shokat, Kevan M; Kruse, Andrew C; García-Sastre, Adolfo; Schwartz, Olivier; Moretti, Francesca; Vignuzzi, Marco; Pognan, Francois; Shoichet, Brian K.
Affiliation
  • Tummino TA; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.
  • Rezelj VV; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, UCSF, San Francisco, CA, USA.
  • Fischer B; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.
  • Fischer A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.
  • O'Meara MJ; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France.
  • Monel B; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland.
  • Vallet T; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland.
  • White KM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Zhang Z; Institut Pasteur, Virus and Immunity Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France.
  • Alon A; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75724 Paris, Cedex 15, France.
  • Schadt H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • O'Donnell HR; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Lyu J; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.
  • Rosales R; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.
  • McGovern BL; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, USA.
  • Rathnasinghe R; Howard Hughes Medical Institute, UCSF, San Francisco, CA, USA.
  • Jangra S; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
  • Schotsaert M; Novartis Institutes for BioMedical Research, Preclinical Safety, Basel, Switzerland.
  • Galarneau JR; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.
  • Krogan NJ; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.
  • Urban L; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, CA, USA.
  • Shokat KM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.
  • Kruse AC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • García-Sastre A; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schwartz O; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Moretti F; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Vignuzzi M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pognan F; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Shoichet BK; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Science ; 373(6554): 541-547, 2021 07 30.
Article in En | MEDLINE | ID: mdl-34326236
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phospholipids / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment / Lipidoses Type of study: Screening_studies Limits: Animals / Female / Humans Language: En Journal: Science Year: 2021 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phospholipids / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment / Lipidoses Type of study: Screening_studies Limits: Animals / Female / Humans Language: En Journal: Science Year: 2021 Type: Article Affiliation country: United States