Anti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches.

Khella, Christine M; Horvath, Judith M; Asgarian, Rojiar; Rolauffs, Bernd; Hart, Melanie L

Khella, Christine M; Horvath, Judith M; Asgarian, Rojiar; Rolauffs, Bernd; Hart, Melanie L.

Affiliation

Khella CM; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.
Horvath JM; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.
Asgarian R; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.
Rolauffs B; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.
Hart ML; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.

Int J Mol Sci ; 22(15)2021 Jul 27.

Article in En | MEDLINE | ID: mdl-34360771

Subject(s)

Anti-Inflammatory Agents/therapeutic use; Knee Injuries; Osteoarthritis, Knee; Animals; Cartilage, Articular/metabolism; Cartilage, Articular/pathology; Humans; Knee Injuries/complications; Knee Injuries/drug therapy; Knee Injuries/metabolism; Knee Injuries/pathology; Knee Joint/metabolism; Knee Joint/pathology; Osteoarthritis, Knee/drug therapy; Osteoarthritis, Knee/etiology; Osteoarthritis, Knee/metabolism; Osteoarthritis, Knee/pathology

Key words

IL-1 receptor antagonist; IL-10; IL-13; IL-1ß; IL-4; IL-6; TNF-α; anti-apoptotic; anti-inflammatory cytokines; antibody; articular cartilage; cartilage; cartilage repair; chondrocyte; clinical; complement inhibitors; complement system; degeneration; dexamethasone; drug delivery; early PTOA; early disease; fat pad; hyaluronic acid; immunomodulation; inflammation; knee joint; knee trauma; osteoarthritis; post-traumatic osteoarthritis; prevention; regeneration; synovium; tranexamic acid; triamcinolone acetonide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis, Knee / Knee Injuries / Anti-Inflammatory Agents Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Germany

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