The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation.

Toki, Shunichi; Yoshimaru, Tetsuro; Matsushita, Yosuke; Aihara, Hitoshi; Ono, Masaya; Tsuneyama, Koichi; Sairyo, Koichi; Katagiri, Toyomasa

Toki, Shunichi; Yoshimaru, Tetsuro; Matsushita, Yosuke; Aihara, Hitoshi; Ono, Masaya; Tsuneyama, Koichi; Sairyo, Koichi; Katagiri, Toyomasa.

Affiliation

Toki S; Division of Genome Medicine, Advanced Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Yoshimaru T; Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Matsushita Y; Division of Genome Medicine, Advanced Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Aihara H; Division of Genome Medicine, Advanced Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Ono M; Division of Genome Medicine, Advanced Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
Tsuneyama K; Department of Proteomics, National Cancer Center Research Institute, Tokyo, Japan.
Sairyo K; Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Katagiri T; Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Cancer Sci ; 112(10): 4208-4219, 2021 Oct.

Article in En | MEDLINE | ID: mdl-34363714

Subject(s)

Bone Neoplasms/pathology; Cell Proliferation/physiology; Cell Survival/physiology; Guanine Nucleotide Exchange Factors/physiology; Mitochondria/metabolism; Osteosarcoma/pathology; Repressor Proteins/physiology; Animals; Apoptosis/physiology; Apoptosis Inducing Factor/metabolism; Bone Neoplasms/metabolism; Bone Neoplasms/therapy; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell-Penetrating Peptides/pharmacology; Databases, Factual; Down-Regulation; G2 Phase Cell Cycle Checkpoints; Gene Silencing; Guanine Nucleotide Exchange Factors/drug effects; Guanine Nucleotide Exchange Factors/metabolism; Humans; M Phase Cell Cycle Checkpoints; Membrane Proteins/metabolism; Mice; Mice, Nude; Mitochondrial Membranes/metabolism; Neoplasm Invasiveness; Neoplasm Transplantation; Osteosarcoma/metabolism; Osteosarcoma/therapy; Poly (ADP-Ribose) Polymerase-1/metabolism; Prohibitins; RNA, Small Interfering/metabolism; Repressor Proteins/drug effects; Repressor Proteins/metabolism

Key words

BIG3; PHB2; mitochondria; osteosarcoma; peptide inhibitor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Bone Neoplasms / Osteosarcoma / Cell Survival / Guanine Nucleotide Exchange Factors / Cell Proliferation / Mitochondria Limits: Animals / Humans Language: En Journal: Cancer Sci Year: 2021 Type: Article Affiliation country: Japan

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