A three-pocket model for substrate coordination and selectivity by the nucleotide sugar transporters SLC35A1 and SLC35A2.

Li, Danyang; Mukhopadhyay, Somshuvra

Li, Danyang; Mukhopadhyay, Somshuvra.

Affiliation

Li D; Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, USA.
Mukhopadhyay S; Division of Pharmacology & Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, Texas, USA. Electronic address: som@austin.utexas.edu.

J Biol Chem ; 297(3): 101069, 2021 09.

Article in En | MEDLINE | ID: mdl-34384782

Subject(s)

Monosaccharide Transport Proteins/genetics; Nucleotide Transport Proteins/genetics; Animals; CHO Cells; Cricetulus; Glycosylation; HeLa Cells; Humans; Membrane Transport Proteins/metabolism; Monosaccharide Transport Proteins/metabolism; Monosaccharide Transport Proteins/ultrastructure; Mutation; Nucleotide Transport Proteins/metabolism; Nucleotide Transport Proteins/ultrastructure; Nucleotides/metabolism; Substrate Specificity

Key words

mutagenesis; nucleotide sugar transporters; rescue assays; structural determinants; substrate specificity; three-pocket model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monosaccharide Transport Proteins / Nucleotide Transport Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Type: Article Affiliation country: United States

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