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CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.
Boutin, J; Rosier, J; Cappellen, D; Prat, F; Toutain, J; Pennamen, P; Bouron, J; Rooryck, C; Merlio, J P; Lamrissi-Garcia, I; Cullot, G; Amintas, S; Guyonnet-Duperat, V; Ged, C; Blouin, J M; Richard, E; Dabernat, S; Moreau-Gaudry, F; Bedel, A.
Affiliation
  • Boutin J; Bordeaux University, Bordeaux, France.
  • Rosier J; INSERM U1035, Biotherapy of Genetic Diseases, Inflammatory disorders and Cancers, Bordeaux, France.
  • Cappellen D; University Hospital Bordeaux, Biochemistry Laboratory, Bordeaux, France.
  • Prat F; Laboratory of Excellence, Gr-Ex, Bordeaux, France.
  • Toutain J; Bordeaux University, Bordeaux, France.
  • Pennamen P; INSERM U1035, Biotherapy of Genetic Diseases, Inflammatory disorders and Cancers, Bordeaux, France.
  • Bouron J; Laboratory of Excellence, Gr-Ex, Bordeaux, France.
  • Rooryck C; Bordeaux University, Bordeaux, France.
  • Merlio JP; INSERM U1035, Biotherapy of Genetic Diseases, Inflammatory disorders and Cancers, Bordeaux, France.
  • Lamrissi-Garcia I; Laboratory of Excellence, Gr-Ex, Bordeaux, France.
  • Cullot G; University Hospital Bordeaux, Tumor Biology and Tumor Bank Laboratory, Bordeaux, France.
  • Amintas S; Bordeaux University, Bordeaux, France.
  • Guyonnet-Duperat V; INSERM U1035, Biotherapy of Genetic Diseases, Inflammatory disorders and Cancers, Bordeaux, France.
  • Ged C; Laboratory of Excellence, Gr-Ex, Bordeaux, France.
  • Blouin JM; Bordeaux University, MRGM INSERM U1211, CHU de Bordeaux, Service de Génétique Médicale, Bordeaux, France.
  • Richard E; Bordeaux University, MRGM INSERM U1211, CHU de Bordeaux, Service de Génétique Médicale, Bordeaux, France.
  • Dabernat S; Bordeaux University, MRGM INSERM U1211, CHU de Bordeaux, Service de Génétique Médicale, Bordeaux, France.
  • Moreau-Gaudry F; Bordeaux University, Bordeaux, France.
  • Bedel A; Bordeaux University, MRGM INSERM U1211, CHU de Bordeaux, Service de Génétique Médicale, Bordeaux, France.
Nat Commun ; 12(1): 4922, 2021 08 13.
Article in En | MEDLINE | ID: mdl-34389729
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Globins / Hematopoietic Stem Cells / Sequence Deletion / Loss of Heterozygosity / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Globins / Hematopoietic Stem Cells / Sequence Deletion / Loss of Heterozygosity / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: France