Expanding the potential genes of inborn errors of immunity through protein interactions.
BMC Genomics
; 22(1): 618, 2021 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-34391382
ABSTRACT
BACKGROUND:
Inborn errors of immunity (IEI) are a group of genetic disorders that impair the immune system, with over 400 genes described so far, and hundreds more to be discovered. To facilitate the search for new genes, we need a way to prioritize among all the genes in the genome those most likely to play an important role in immunity.RESULTS:
Here we identify a new list of genes by linking known IEI genes to new ones by using open-source databases of protein-protein interactions, post-translational modifications, and transcriptional regulation. We analyze this new set of 2,530 IEI-related genes for their tolerance of genetic variation and by their expression levels in various immune cell types.CONCLUSIONS:
By merging genes derived from protein interactions of known IEI genes with transcriptional data, we offer a new list of candidate genes that may play a role in as-yet undiscovered IEIs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immune System
Language:
En
Journal:
BMC Genomics
Journal subject:
GENETICA
Year:
2021
Type:
Article
Affiliation country:
United States