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Electrochemical borylation of carboxylic acids.
Barton, Lisa M; Chen, Longrui; Blackmond, Donna G; Baran, Phil S.
Affiliation
  • Barton LM; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Chen L; Department of Chemistry, Scripps Research, La Jolla, CA 92037.
  • Blackmond DG; Department of Chemistry, Scripps Research, La Jolla, CA 92037 blackmond@scripps.edu pbaran@scripps.edu.
  • Baran PS; Department of Chemistry, Scripps Research, La Jolla, CA 92037 blackmond@scripps.edu pbaran@scripps.edu.
Proc Natl Acad Sci U S A ; 118(34)2021 08 24.
Article in En | MEDLINE | ID: mdl-34404720
ABSTRACT
A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boronic Acids / Carboxylic Acids / Electrodes / Electrochemical Techniques Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boronic Acids / Carboxylic Acids / Electrodes / Electrochemical Techniques Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article