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An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes.
Padhi, Aditya K; Kumar, Ashutosh; Haruna, Ken-Ichi; Sato, Haruna; Tamura, Hiroko; Nagatoishi, Satoru; Tsumoto, Kouhei; Yamaguchi, Atushi; Iraha, Fumie; Takahashi, Mihoko; Sakamoto, Kensaku; Zhang, Kam Y J.
Affiliation
  • Padhi AK; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Kumar A; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Haruna KI; Research Institute for Bioscience Products and Fine Chemicals, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan.
  • Sato H; Research Institute for Bioscience Products and Fine Chemicals, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan.
  • Tamura H; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Nagatoishi S; Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Tsumoto K; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Yamaguchi A; Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  • Iraha F; Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Takahashi M; Division of Structural and Synthetic Biology, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Sakamoto K; Division of Structural and Synthetic Biology, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
  • Zhang KYJ; Division of Structural and Synthetic Biology, Center for Life Science Technologies, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Brief Bioinform ; 22(6)2021 11 05.
Article in En | MEDLINE | ID: mdl-34415295
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Models, Molecular / Single-Domain Antibodies / Genetic Code / Antibody Affinity Type of study: Prognostic_studies Limits: Humans Language: En Journal: Brief Bioinform Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2021 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Models, Molecular / Single-Domain Antibodies / Genetic Code / Antibody Affinity Type of study: Prognostic_studies Limits: Humans Language: En Journal: Brief Bioinform Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2021 Type: Article Affiliation country: Japan