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Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.
Cantet, Gael; Berges, Alienor; O'Sullivan, Rhianna; Cohen-Rabbie, Sarit; Dota, Corina; Dubois, Vincent; Benoist, Guillemette E; Tomkinson, Helen; Rekic, Dinko; Parkinson, Joanna; Schalkwijk, Stein.
Affiliation
  • Cantet G; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Berges A; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • O'Sullivan R; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, UK.
  • Cohen-Rabbie S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Dota C; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Dubois V; Cardiovascular Safety Centre of Excellence, CMO, Oncology R&D, Gothenburg, Sweden.
  • Benoist GE; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Tomkinson H; Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.
  • Rekic D; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Parkinson J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Schalkwijk S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Br J Clin Pharmacol ; 88(3): 1010-1019, 2022 03.
Article in En | MEDLINE | ID: mdl-34416045
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome / Electrocardiography Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Clin Pharmacol Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome / Electrocardiography Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Clin Pharmacol Year: 2022 Type: Article Affiliation country: United kingdom