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ASL expression in ALDH1A1+ neurons in the substantia nigra metabolically contributes to neurodegenerative phenotype.
Lerner, Shaul; Eilam, Raya; Adler, Lital; Baruteau, Julien; Kreiser, Topaz; Tsoory, Michael; Brandis, Alexander; Mehlman, Tevie; Ryten, Mina; Botia, Juan A; Ruiz, Sonia Garcia; Garcia, Alejandro Cisterna; Dionisi-Vici, Carlo; Ranucci, Giusy; Spada, Marco; Mazkereth, Ram; McCarter, Robert; Izem, Rima; Balmat, Thomas J; Richesson, Rachel; Gazit, Ehud; Nagamani, Sandesh C S; Erez, Ayelet.
Affiliation
  • Lerner S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Eilam R; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
  • Adler L; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Baruteau J; Great Ormond Street Institute of Child Health, and NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
  • Kreiser T; Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
  • Tsoory M; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801, Tel Aviv, Israel.
  • Brandis A; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
  • Mehlman T; Life Science Core Facility, Weizmann Institute of Science, Rehovot, Israel.
  • Ryten M; Life Science Core Facility, Weizmann Institute of Science, Rehovot, Israel.
  • Botia JA; Great Ormond Street Institute of Child Health, and NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
  • Ruiz SG; Institute of Neurology, University College London (UCL), London, UK.
  • Garcia AC; Institute of Neurology, University College London (UCL), London, UK.
  • Dionisi-Vici C; Department of Information and Communications Engineering, University of Murcia, Murcia, Spain.
  • Ranucci G; Great Ormond Street Institute of Child Health, and NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
  • Spada M; Institute of Neurology, University College London (UCL), London, UK.
  • Mazkereth R; Department of Information and Communications Engineering, University of Murcia, Murcia, Spain.
  • McCarter R; Division of Metabolism, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Izem R; Division of Metabolism, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Balmat TJ; Division of Metabolism, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
  • Richesson R; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Gazit E; Children's National Medical Center, Washington, D.C., USA.
  • Nagamani SCS; Center for Translational Sciences, Children's National Health System, The George Washington University, Washington, D.C., USA.
  • Erez A; Children's National Medical Center, Washington, D.C., USA.
Hum Genet ; 140(10): 1471-1485, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34417872
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Argininosuccinate Lyase / Dopaminergic Neurons / Aldehyde Dehydrogenase 1 Family Limits: Animals / Humans Language: En Journal: Hum Genet Year: 2021 Type: Article Affiliation country: Israel
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Argininosuccinate Lyase / Dopaminergic Neurons / Aldehyde Dehydrogenase 1 Family Limits: Animals / Humans Language: En Journal: Hum Genet Year: 2021 Type: Article Affiliation country: Israel