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Adverse reactions in a large cohort of patients with inborn errors of immunity receiving intravenous immunoglobulin.
Esmaeilzadeh, Hossein; Askarisarvestani, Aida; Hosseini, Nazanin; Samimi, Sahar; Shafiei, Alireza; Mahdaviani, Seyed Alireza; Eslami, Narges; Chavoshzadeh, Zahra; Fallahi, Mazdak; Khakbazanfard, Nasrin; Shabestari, Mahnaz Sadeghi; Aleyasin, Soheila; Nabavizadeh, Seyed Hesamedin; Cheraghi, Taher; Kalantari, Arash; Ahmadiafshar, Akefeh; Safari, Mojgan; Eslamian, Mohammad Hossein; Molatefi, Rasol; Shirkani, Afshin; Heidarzadeh Arani, Marzieh; Tavakol, Marzieh; Bemanian, Mohammad Hassan; Arshi, Saba; Nabavi, Mohammad; Shokri, Sima; Shahhosseini, Babak; Mortazavi, Negar; Nakhaei, Pooria; Nazari, Farzad; Fallahpour, Morteza; Ahanchian, Hamid; Moazzen, Nasrin; Khoshkhui, Maryam; Motlagh, Ahmad Vosughi; Aghamohammadi, Asghar; Abolhassani, Hassan; Yazdani, Reza; Rezaei, Nima.
Affiliation
  • Esmaeilzadeh H; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Askarisarvestani A; Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Hosseini N; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Samimi S; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Shafiei A; Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahdaviani SA; Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Eslami N; Allergy and Clinical immunology Dept, Mofid Children Hospital, , Shahid Beheshti University of Medical Sciences, Tehran, , Iran.
  • Chavoshzadeh Z; Allergy and Clinical immunology Dept, Mofid Children Hospital, , Shahid Beheshti University of Medical Sciences, Tehran, , Iran.
  • Fallahi M; Allergy and Clinical immunology Dept, Mofid Children Hospital, , Shahid Beheshti University of Medical Sciences, Tehran, , Iran.
  • Khakbazanfard N; Allergy and Clinical immunology Dept, Mofid Children Hospital, , Shahid Beheshti University of Medical Sciences, Tehran, , Iran.
  • Shabestari MS; Department of Immunology and Allergy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Aleyasin S; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Nabavizadeh SH; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Cheraghi T; Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran.
  • Kalantari A; Department of Immunology and Allergy, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ahmadiafshar A; Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Safari M; Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Eslamian MH; Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Molatefi R; Department of Pediatrics, Bo-Ali children's Hospital of Ardabil University of Medical Sciences, Ardabil, Iran.
  • Shirkani A; Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran.
  • Heidarzadeh Arani M; Pediatric Department, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
  • Tavakol M; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Bemanian MH; Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Arshi S; Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Nabavi M; Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Shokri S; Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Shahhosseini B; Division of Allergy and Clinical Immunology, Pediatrics Department, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mortazavi N; Department of Clinical Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Nakhaei P; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Nazari F; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Fallahpour M; Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Ahanchian H; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Moazzen N; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Khoshkhui M; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Motlagh AV; Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd. Iran.
  • Aghamohammadi A; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Abolhassani H; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Division of Clinical Immunology,
  • Yazdani R; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  • Rezaei N; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
Clin Immunol ; 230: 108826, 2021 09.
Article in En | MEDLINE | ID: mdl-34418548
ABSTRACT

BACKGROUND:

Intravenous immunoglobulins (IVIg) are the major treatment in inborn errors of immunity (IEI) disorders; However, IVIg infusions show some adverse effects. We aimed to assess the adverse reactions of IVIg infusions.

METHODS:

Data of IVIg infusions in IEI patients were collected from 2011 to 2021. Totally, 363 IEI patients received IVIg regularly in Iran entered the study. The adverse reactions are classified regarding their severity and chronicity.

RESULTS:

22,667 IVIg infusions were performed in the study. 157 patients (43.2%) and 1349 (5.9%) infusions were associated with at least one type of adverse reaction. The highest rates of adverse reactions were seen in severe combined immunodeficiency. Myalgia, chills, headache, fever, and hypotension were the most frequent adverse effects of IVIg.

CONCLUSION:

The reactions affect almost half of the patients mainly in the first infusions which necessitate the close observation of IEI patients receiving IVIg.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulins, Intravenous / Immunologic Deficiency Syndromes Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: Iran
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulins, Intravenous / Immunologic Deficiency Syndromes Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: Iran