Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.

Neuberger, Arthur; Nadezhdin, Kirill D; Zakharian, Eleonora; Sobolevsky, Alexander I

Neuberger, Arthur; Nadezhdin, Kirill D; Zakharian, Eleonora; Sobolevsky, Alexander I.

Affiliation

Neuberger A; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Nadezhdin KD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Zakharian E; Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine, Peoria, IL, USA.
Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

EMBO Rep ; 22(11): e53233, 2021 11 04.

Article in En | MEDLINE | ID: mdl-34472684

Subject(s)

Coumarins; TRPV Cation Channels; Coumarins/metabolism; Coumarins/pharmacology; Humans; Keratinocytes/metabolism; Skin/metabolism; TRPV Cation Channels/metabolism

Key words

TRP channels; competitive inhibitor; cryo-EM; osthole; single-channel recordings

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coumarins / TRPV Cation Channels Limits: Humans Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United States

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