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Cervical cancer prevention and control in women living with human immunodeficiency virus.
Castle, Philip E; Einstein, Mark H; Sahasrabuddhe, Vikrant V.
Affiliation
  • Castle PE; Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
  • Einstein MH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
  • Sahasrabuddhe VV; Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey.
CA Cancer J Clin ; 71(6): 505-526, 2021 11.
Article in En | MEDLINE | ID: mdl-34499351
ABSTRACT
Despite being highly preventable, cervical cancer is the fourth most common cancer and cause of cancer death in women globally. In low-income countries, cervical cancer is often the leading cause of cancer-related morbidity and mortality. Women living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome are at a particularly high risk of cervical cancer because of an impaired immune response to human papillomavirus, the obligate cause of virtually all cervical cancers. Globally, approximately 1 in 20 cervical cancers is attributable to HIV; in sub-Saharan Africa, approximately 1 in 5 cervical cancers is due to HIV. Here, the authors provide a critical appraisal of the evidence to date on the impact of HIV disease on cervical cancer risk, describe key methodologic issues, and frame the key outstanding research questions, especially as they apply to ongoing global efforts for prevention and control of cervical cancer. Expanded efforts to integrate HIV care with cervical cancer prevention and control, and vice versa, could assist the global effort to eliminate cervical cancer as a public health problem.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Uterine Cervical Neoplasms Type of study: Diagnostic_studies / Screening_studies Limits: Female / Humans Language: En Journal: CA Cancer J Clin Year: 2021 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Uterine Cervical Neoplasms Type of study: Diagnostic_studies / Screening_studies Limits: Female / Humans Language: En Journal: CA Cancer J Clin Year: 2021 Type: Article