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Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): a randomised, double-blind, placebo-controlled, phase 2 trial.
Pinto, Carmine; Zucali, Paolo Andrea; Pagano, Maria; Grosso, Federica; Pasello, Giulia; Garassino, Marina Chiara; Tiseo, Marcello; Soto Parra, Hector; Grossi, Francesco; Cappuzzo, Federico; de Marinis, Filippo; Pedrazzoli, Paolo; Bonomi, Maria; Gianoncelli, Letizia; Perrino, Matteo; Santoro, Armando; Zanelli, Francesca; Bonelli, Candida; Maconi, Antonio; Frega, Stefano; Gervasi, Erika; Boni, Luca; Ceresoli, Giovanni Luca.
Affiliation
  • Pinto C; Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Zucali PA; Department of Biomedical Sciences, Humanitas University, Milan, Italy; Department of Oncology, IRCCS Humanitas Research Hospital, Milan, Italy. Electronic address: paolo.zucali@hunimed.eu.
  • Pagano M; Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Grosso F; Mesothelioma Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; Infrastruttura Ricerca Formazione e Innovazione, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Pasello G; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.
  • Garassino MC; Thoracic Oncology Unit, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Tiseo M; Department of Medicine and Surgery, University of Parma, Parma, Italy; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
  • Soto Parra H; Medical Oncology Unit, AOU Policlinico Vittorio Emanuele, Catania, Italy.
  • Grossi F; Medical Oncology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore, Milan, Italy; Medical Oncology Unit, University of Insubria, Varese, Italy.
  • Cappuzzo F; Medical Oncology Unit, IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy.
  • de Marinis F; Thoracic Oncology Division, Istituto Europeo di Oncologia IRCCS, Milan, Italy.
  • Pedrazzoli P; Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.
  • Bonomi M; Department of Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy; Department of Oncology, ASST Cremona, Cremona, Italy.
  • Gianoncelli L; Department of Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy; Department of Oncology, Ospedale San Paolo, Milan, Italy.
  • Perrino M; Department of Oncology, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Santoro A; Department of Biomedical Sciences, Humanitas University, Milan, Italy; Department of Oncology, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Zanelli F; Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Bonelli C; Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Maconi A; Infrastruttura Ricerca Formazione e Innovazione, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Frega S; Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.
  • Gervasi E; Medical Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
  • Boni L; Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Ceresoli GL; Department of Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy.
Lancet Oncol ; 22(10): 1438-1447, 2021 10.
Article in En | MEDLINE | ID: mdl-34499874
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pleural Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Deoxycytidine / Antibodies, Monoclonal, Humanized / Mesothelioma, Malignant Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pleural Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Deoxycytidine / Antibodies, Monoclonal, Humanized / Mesothelioma, Malignant Type of study: Clinical_trials / Diagnostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Italy