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Recent Advancements in the Medical Treatment of Diabetic Retinal Disease.
Szymanska, Maja; Mahmood, Daanyaal; Yap, Timothy E; Cordeiro, Maria F.
Affiliation
  • Szymanska M; The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
  • Mahmood D; The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
  • Yap TE; The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
  • Cordeiro MF; The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK.
Int J Mol Sci ; 22(17)2021 Aug 31.
Article in En | MEDLINE | ID: mdl-34502350
ABSTRACT
Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, intravitreal therapy commonly requires frequent hospital visits and some patients fail to achieve a significant improvement in vision. Novel and long-acting therapies targeting a range of pathways are warranted, while evidence to support optimal combinations of treatments is currently insufficient. Improved understanding of the molecular pathways involved in pathogenesis is driving the development of therapeutic agents not only targeting visible microvascular disease and metabolic derangements, but also inflammation and accelerated retinal neurodegeneration. This review summarizes the current and emerging treatments of diabetic retinal diseases and provides an insight into the future of managing this important condition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Complications / Diabetic Retinopathy Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Complications / Diabetic Retinopathy Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: United kingdom