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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Brehmer, Dirk; Beke, Lijs; Wu, Tongfei; Millar, Hillary J; Moy, Christopher; Sun, Weimei; Mannens, Geert; Pande, Vineet; Boeckx, An; van Heerde, Erika; Nys, Thomas; Gustin, Emmanuel M; Verbist, Bie; Zhou, Longen; Fan, Yue; Bhargava, Vipul; Safabakhsh, Pegah; Vinken, Petra; Verhulst, Tinne; Gilbert, Angelique; Rai, Sumit; Graubert, Timothy A; Pastore, Friederike; Fiore, Danilo; Gu, Junchen; Johnson, Amy; Philippar, Ulrike; Morschhäuser, Barbara; Walker, David; De Lange, Desiree; Keersmaekers, Vikki; Viellevoye, Marcel; Diels, Gaston; Schepens, Wim; Thuring, Jan Willem; Meerpoel, Lieven; Packman, Kathryn; Lorenzi, Matthew V; Laquerre, Sylvie.
Affiliation
  • Brehmer D; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Beke L; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Wu T; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Millar HJ; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Moy C; Janssen Research and Development, Spring House, Pennsylvania.
  • Sun W; Janssen Research and Development, Spring House, Pennsylvania.
  • Mannens G; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Pande V; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Boeckx A; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • van Heerde E; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Nys T; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Gustin EM; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Verbist B; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Zhou L; Janssen Research and Development, Shanghai, China.
  • Fan Y; Janssen Research and Development, Shanghai, China.
  • Bhargava V; Janssen Research and Development, Spring House, Pennsylvania.
  • Safabakhsh P; Janssen Research and Development, Spring House, Pennsylvania.
  • Vinken P; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Verhulst T; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Gilbert A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.
  • Rai S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.
  • Graubert TA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.
  • Pastore F; Janssen Research and Development, Spring House, Pennsylvania.
  • Fiore D; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Gu J; Janssen Research and Development, Spring House, Pennsylvania.
  • Johnson A; Janssen Research and Development, Spring House, Pennsylvania.
  • Philippar U; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Morschhäuser B; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Walker D; Janssen Research and Development, Spring House, Pennsylvania.
  • De Lange D; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Keersmaekers V; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Viellevoye M; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Diels G; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Schepens W; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Thuring JW; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Meerpoel L; Janssen Research and Development, Beerse, Antwerp, Belgium.
  • Packman K; Janssen Research and Development, Spring House, Pennsylvania.
  • Lorenzi MV; Janssen Research and Development, Spring House, Pennsylvania.
  • Laquerre S; Janssen Research and Development, Spring House, Pennsylvania. slaquerr@its.jnj.com.
Mol Cancer Ther ; 20(12): 2317-2328, 2021 12.
Article in En | MEDLINE | ID: mdl-34583982
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Pyrimidines / Pyrroles / Enzyme Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2021 Type: Article Affiliation country: Belgium
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Pyrimidines / Pyrroles / Enzyme Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2021 Type: Article Affiliation country: Belgium