Your browser doesn't support javascript.
loading
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group.
Harrewijn, Anita; Cardinale, Elise M; Groenewold, Nynke A; Bas-Hoogendam, Janna Marie; Aghajani, Moji; Hilbert, Kevin; Cardoner, Narcis; Porta-Casteràs, Daniel; Gosnell, Savannah; Salas, Ramiro; Jackowski, Andrea P; Pan, Pedro M; Salum, Giovanni A; Blair, Karina S; Blair, James R; Hammoud, Mira Z; Milad, Mohammed R; Burkhouse, Katie L; Phan, K Luan; Schroeder, Heidi K; Strawn, Jeffrey R; Beesdo-Baum, Katja; Jahanshad, Neda; Thomopoulos, Sophia I; Buckner, Randy; Nielsen, Jared A; Smoller, Jordan W; Soares, Jair C; Mwangi, Benson; Wu, Mon-Ju; Zunta-Soares, Giovana B; Assaf, Michal; Diefenbach, Gretchen J; Brambilla, Paolo; Maggioni, Eleonora; Hofmann, David; Straube, Thomas; Andreescu, Carmen; Berta, Rachel; Tamburo, Erica; Price, Rebecca B; Manfro, Gisele G; Agosta, Federica; Canu, Elisa; Cividini, Camilla; Filippi, Massimo; Kostic, Milutin; Munjiza Jovanovic, Ana; Alberton, Bianca A V; Benson, Brenda.
Affiliation
  • Harrewijn A; Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA. anita.harrewijn@nih.gov.
  • Cardinale EM; Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
  • Groenewold NA; Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Bas-Hoogendam JM; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
  • Aghajani M; Department of Developmental and Educational Psychology, Institute of Psychology, Leiden University, Leiden, The Netherlands.
  • Hilbert K; Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
  • Cardoner N; Department of Psychiatry, Amsterdam UMC, location VUMC, Amsterdam, The Netherlands.
  • Porta-Casteràs D; Department of Research & Innovation, GGZ InGeest, Amsterdam, The Netherlands.
  • Gosnell S; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Salas R; Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain.
  • Jackowski AP; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Pan PM; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
  • Salum GA; Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain.
  • Blair KS; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Blair JR; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
  • Hammoud MZ; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
  • Milad MR; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
  • Burkhouse KL; LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.
  • Phan KL; LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.
  • Schroeder HK; Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Strawn JR; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.
  • Beesdo-Baum K; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.
  • Jahanshad N; Department of Psychiatry, NYU School of Medicine, New York University, New York, NY, USA.
  • Thomopoulos SI; Department of Psychiatry, NYU School of Medicine, New York University, New York, NY, USA.
  • Buckner R; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
  • Nielsen JA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA.
  • Smoller JW; Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
  • Soares JC; Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
  • Mwangi B; Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • Wu MJ; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Zunta-Soares GB; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
  • Assaf M; Center for Brain Science & Department of Psychology, Harvard University, Cambridge, MA, USA.
  • Diefenbach GJ; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Brambilla P; Center for Brain Science & Department of Psychology, Harvard University, Cambridge, MA, USA.
  • Maggioni E; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Hofmann D; Psychology Department & Neuroscience Center, Brigham Young University, Provo, USA.
  • Straube T; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Andreescu C; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Berta R; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Tamburo E; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Price RB; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Manfro GG; Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.
  • Agosta F; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Canu E; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Cividini C; Anxiety Disorders Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.
  • Filippi M; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Kostic M; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
  • Munjiza Jovanovic A; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Alberton BAV; Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany.
  • Benson B; Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany.
Transl Psychiatry ; 11(1): 502, 2021 10 01.
Article in En | MEDLINE | ID: mdl-34599145
ABSTRACT
The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5-90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are small, possibly reflecting heterogeneity or those structural alterations are not a major component of its pathophysiology.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety Disorders / Brain Type of study: Diagnostic_studies Limits: Adult / Child / Female / Humans / Male Language: En Journal: Transl Psychiatry Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety Disorders / Brain Type of study: Diagnostic_studies Limits: Adult / Child / Female / Humans / Male Language: En Journal: Transl Psychiatry Year: 2021 Type: Article Affiliation country: United States