4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor ß, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1.

Hirao-Suzuki, Masayo; Nagase, Keita; Suemori, Tatsuya; Tsutsumi, Kana; Shigemori, Egao; Tanaka, Michitaka; Takiguchi, Masufumi; Sugihara, Narumi; Yoshihara, Shin'ichi; Takeda, Shuso

Hirao-Suzuki, Masayo; Nagase, Keita; Suemori, Tatsuya; Tsutsumi, Kana; Shigemori, Egao; Tanaka, Michitaka; Takiguchi, Masufumi; Sugihara, Narumi; Yoshihara, Shin'ichi; Takeda, Shuso.

Affiliation

Hirao-Suzuki M; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Nagase K; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Suemori T; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Tsutsumi K; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Shigemori E; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Tanaka M; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Takiguchi M; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Sugihara N; Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University.
Yoshihara S; Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University.
Takeda S; Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University.

Biol Pharm Bull ; 44(10): 1524-1529, 2021.

Article in En | MEDLINE | ID: mdl-34602561

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Breast Neoplasms/drug therapy; Cyclopentanes/pharmacology; Estrogen Receptor beta/antagonists & inhibitors; Phenols/pharmacology; Quinolines/pharmacology; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Breast Neoplasms/pathology; Cell Proliferation/drug effects; Cyclopentanes/therapeutic use; Drug Resistance, Neoplasm/drug effects; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Phenols/therapeutic use; Quinolines/therapeutic use; Receptors, Estrogen/metabolism; Receptors, G-Protein-Coupled/agonists; Receptors, G-Protein-Coupled/metabolism; Signal Transduction/drug effects

Key words

4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP); G protein-coupled estrogen receptor 1 (GPER1); MCF-7; bisphenol A (BPA)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Quinolines / Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Cyclopentanes / Estrogen Receptor beta Limits: Female / Humans Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2021 Type: Article

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