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Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition.
Kihara, Takako; Yuan, Jiayin; Watabe, Tadashi; Kitajima, Kazuhiro; Kimura, Neinei; Ohkouchi, Mizuka; Hashikura, Yuka; Ohkubo, Shuichi; Takahashi, Tsuyoshi; Hirota, Seiichi.
Affiliation
  • Kihara T; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Yuan J; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Watabe T; Department of Radiology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Kitajima K; Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Kimura N; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Ohkouchi M; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Hashikura Y; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Ohkubo S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co. Ltd, Tsukuba, Japan.
  • Takahashi T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
  • Hirota S; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: hiros@hyo-med.ac.jp.
Exp Mol Pathol ; 123: 104692, 2021 12.
Article in En | MEDLINE | ID: mdl-34606780
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Benzamides / Proto-Oncogene Proteins c-kit / Gastrointestinal Stromal Tumors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Exp Mol Pathol Year: 2021 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Benzamides / Proto-Oncogene Proteins c-kit / Gastrointestinal Stromal Tumors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Exp Mol Pathol Year: 2021 Type: Article Affiliation country: Japan