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Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment.
Lam, Khiem C; Araya, Romina E; Huang, April; Chen, Quanyi; Di Modica, Martina; Rodrigues, Richard R; Lopès, Amélie; Johnson, Sarah B; Schwarz, Benjamin; Bohrnsen, Eric; Cogdill, Alexandria P; Bosio, Catharine M; Wargo, Jennifer A; Lee, Maxwell P; Goldszmid, Romina S.
Affiliation
  • Lam KC; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Araya RE; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Huang A; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Leidos Biomedical Research, Bethesda, MD 20892, USA.
  • Chen Q; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Kelly Government Solutions, Bethesda, MD 20892, USA.
  • Di Modica M; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
  • Rodrigues RR; Leidos Biomedical Research, Bethesda, MD 20892, USA; Microbiome and Genetics Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Lopès A; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Johnson SB; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Schwarz B; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
  • Bohrnsen E; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
  • Cogdill AP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Bosio CM; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
  • Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Lee MP; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Goldszmid RS; Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.
Cell ; 184(21): 5338-5356.e21, 2021 10 14.
Article in En | MEDLINE | ID: mdl-34624222
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Interferon Type I / Tumor Microenvironment / Microbiota / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Interferon Type I / Tumor Microenvironment / Microbiota / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States