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Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure.
Garai, Sumanta; Schaffer, Peter C; Laprairie, Robert B; Janero, David R; Pertwee, Roger G; Straiker, Alex; Thakur, Ganesh A.
Affiliation
  • Garai S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
  • Schaffer PC; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
  • Laprairie RB; College of Pharmacy and Nutrition, University of Saskatchewan, 104 Clinic Pl, Saskatoon, SK S7N2Z4, Canada.
  • Janero DR; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
  • Pertwee RG; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK.
  • Straiker A; Program in Neuroscience, Indiana University, Bloomington, Indiana Gill Center for Biomolecular Science, Bloomington, IN 47405, United States.
  • Thakur GA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
Bioorg Med Chem ; 50: 116421, 2021 11 15.
Article in En | MEDLINE | ID: mdl-34634617
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Receptor, Cannabinoid, CB1 / Cannabinoid Receptor Agonists / Indoles Type of study: Guideline / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Receptor, Cannabinoid, CB1 / Cannabinoid Receptor Agonists / Indoles Type of study: Guideline / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: United States