Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses.

Paidi, Ramesh K; Jana, Malabendu; Mishra, Rama K; Dutta, Debashis; Pahan, Kalipada

Paidi, Ramesh K; Jana, Malabendu; Mishra, Rama K; Dutta, Debashis; Pahan, Kalipada.

Affiliation

Paidi RK; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Jana M; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Mishra RK; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL; and.
Dutta D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
Pahan K; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL; kalipada_pahan@rush.edu.

J Immunol ; 207(10): 2521-2533, 2021 11 15.

Article in En | MEDLINE | ID: mdl-34645689

Subject(s)

Angiotensin-Converting Enzyme 2/metabolism; Anti-Inflammatory Agents/therapeutic use; COVID-19/therapy; Lung/immunology; Peptides/metabolism; SARS-CoV-2/physiology; Spike Glycoprotein, Coronavirus/metabolism; A549 Cells; Angiotensin-Converting Enzyme 2/genetics; Animals; COVID-19/immunology; Cytokines/metabolism; Female; HEK293 Cells; Humans; Inflammation Mediators/metabolism; Locomotion; Male; Mice; Molecular Targeted Therapy; NF-kappa B/metabolism; Peptides/genetics; Peptides/therapeutic use; Signal Transduction; Spike Glycoprotein, Coronavirus/genetics; Spike Glycoprotein, Coronavirus/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 / Lung / Anti-Inflammatory Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Immunol Year: 2021 Type: Article Affiliation country: Israel

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