Effect of corticosteroid dosing on outcomes in high-grade immune checkpoint inhibitor hepatitis.

Li, Michael; Wong, Danny; Vogel, Alexander S; Sack, Jordan S; Rahma, Osama E; Hodi, F Stephen; Zucker, Stephen D; Grover, Shilpa

Li, Michael; Wong, Danny; Vogel, Alexander S; Sack, Jordan S; Rahma, Osama E; Hodi, F Stephen; Zucker, Stephen D; Grover, Shilpa.

Affiliation

Li M; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Wong D; Harvard Medical School, Boston, Massachusetts, USA.
Vogel AS; Division of Gastroenterology, University of California San Francisco, San Francisco, California, USA.
Sack JS; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Rahma OE; Harvard Medical School, Boston, Massachusetts, USA.
Hodi FS; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Zucker SD; Harvard Medical School, Boston, Massachusetts, USA.
Grover S; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham & Women's Hospital, Boston, Massachusetts, USA.

Hepatology ; 75(3): 531-540, 2022 03.

Article in En | MEDLINE | ID: mdl-34709662

Subject(s)

Alanine Transaminase/blood; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Immune Checkpoint Inhibitors/adverse effects; Methylprednisolone; Adrenal Cortex Hormones/administration & dosage; Adrenal Cortex Hormones/adverse effects; Chemical and Drug Induced Liver Injury/blood; Chemical and Drug Induced Liver Injury/diagnosis; Chemical and Drug Induced Liver Injury/drug therapy; Chemical and Drug Induced Liver Injury/etiology; Drug Resistance; Female; Humans; Immune Checkpoint Inhibitors/administration & dosage; Immunosuppression Therapy/methods; Liver Function Tests/methods; Male; Methylprednisolone/administration & dosage; Methylprednisolone/adverse effects; Middle Aged; Neoplasms/drug therapy; Outcome and Process Assessment, Health Care; Retrospective Studies; Risk Assessment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylprednisolone / Alanine Transaminase / Dose-Response Relationship, Drug / Dose-Response Relationship, Immunologic / Chemical and Drug Induced Liver Injury / Immune Checkpoint Inhibitors Type of study: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Hepatology Year: 2022 Type: Article Affiliation country: United States

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