Vitamin B6 prevents Isocarbophos-induced posterior cerebral artery injury in offspring rats through up-regulating S1P receptor expression.

Liu, Yanhua; Yang, Kunli; Wang, Ling; Yang, Jinfang; Wang, Yang; Luo, Hu; Li, Peng; Yin, Yaling

Liu, Yanhua; Yang, Kunli; Wang, Ling; Yang, Jinfang; Wang, Yang; Luo, Hu; Li, Peng; Yin, Yaling.

Affiliation

Liu Y; College of pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Yang K; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China.
Wang L; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Yang J; Department of Physiology, North Sichuan Medical College, Nanchong 637007, China.
Wang Y; College of pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
Luo H; Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang 453003, China.
Li P; Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang 453003, China.
Yin Y; The First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, China.

Acta Biochim Biophys Sin (Shanghai) ; 53(12): 1691-1701, 2021 Dec 08.

Article in En | MEDLINE | ID: mdl-34718372

Subject(s)

Cerebral Arterial Diseases/prevention & control; Posterior Cerebral Artery/drug effects; Protective Agents/pharmacology; Sphingosine-1-Phosphate Receptors/metabolism; Vitamin B 6/pharmacology; Acid-Base Equilibrium/drug effects; Animals; Apoptosis/drug effects; Caspase 3/metabolism; Cerebral Arterial Diseases/pathology; Cytokines/metabolism; Disease Models, Animal; Female; Hypoxia/chemically induced; Hypoxia/prevention & control; Insecticides/toxicity; Lysophospholipids/metabolism; Malathion/analogs & derivatives; Malathion/toxicity; Male; Malondialdehyde/blood; Malondialdehyde/metabolism; Maternal Exposure/adverse effects; Nitric Oxide/blood; Nitric Oxide/metabolism; Paternal Exposure/adverse effects; Posterior Cerebral Artery/injuries; Posterior Cerebral Artery/pathology; Protective Agents/therapeutic use; Rats, Sprague-Dawley; Sphingosine/analogs & derivatives; Sphingosine/metabolism; Superoxide Dismutase/blood; Superoxide Dismutase/metabolism; Up-Regulation; Vasoconstriction/drug effects; Vitamin B 6/therapeutic use

Key words

Isocarbophos; offspring rats; sphingosine-1-phosphate (S1P) receptor; vascular dysfunction; vitamin B6

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Arterial Diseases / Protective Agents / Posterior Cerebral Artery / Vitamin B 6 / Sphingosine-1-Phosphate Receptors Language: En Journal: Acta Biochim Biophys Sin (Shanghai) Journal subject: BIOFISICA / BIOQUIMICA Year: 2021 Type: Article Affiliation country: China

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