An Aicardi-Goutières Syndrome-Causative Point Mutation in <i>Adar1</i> Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

Inoue, Maal; Nakahama, Taisuke; Yamasaki, Ryuichiro; Shibuya, Toshiharu; Kim, Jung In; Todo, Hiroyuki; Xing, Yanfang; Kato, Yuki; Morii, Eiichi; Kawahara, Yukio

An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

Inoue, Maal; Nakahama, Taisuke; Yamasaki, Ryuichiro; Shibuya, Toshiharu; Kim, Jung In; Todo, Hiroyuki; Xing, Yanfang; Kato, Yuki; Morii, Eiichi; Kawahara, Yukio.

Affiliation

Inoue M; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Nakahama T; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yamasaki R; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Shibuya T; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kim JI; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Todo H; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Xing Y; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kato Y; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Morii E; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Kawahara Y; Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan; and.

J Immunol ; 207(12): 3016-3027, 2021 12 15.

Article in En | MEDLINE | ID: mdl-34772697

Subject(s)

Adenosine Deaminase; Brain Diseases; Adenosine Deaminase/genetics; Adenosine Deaminase/metabolism; Animals; Autoimmune Diseases of the Nervous System; Inflammation/genetics; Inflammation/metabolism; Mice; Mutation; Nervous System Malformations; Point Mutation; Protein Isoforms/genetics; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Diseases / Adenosine Deaminase Limits: Animals Language: En Journal: J Immunol Year: 2021 Type: Article Affiliation country: Japan

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