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SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains.
Radvak, Peter; Kwon, Hyung-Joon; Kosikova, Martina; Ortega-Rodriguez, Uriel; Xiang, Ruoxuan; Phue, Je-Nie; Shen, Rong-Fong; Rozzelle, James; Kapoor, Neeraj; Rabara, Taylor; Fairman, Jeff; Xie, Hang.
Affiliation
  • Radvak P; Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Kwon HJ; Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Kosikova M; Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Ortega-Rodriguez U; Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Xiang R; Division of Biostatistics, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Phue JN; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Shen RF; Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA.
  • Rozzelle J; Vaxcyte, Inc, Foster City, CA, USA.
  • Kapoor N; Vaxcyte, Inc, Foster City, CA, USA.
  • Rabara T; Vaxcyte, Inc, Foster City, CA, USA.
  • Fairman J; Vaxcyte, Inc, Foster City, CA, USA.
  • Xie H; Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA. Hang.Xie@fda.hhs.gov.
Nat Commun ; 12(1): 6559, 2021 11 12.
Article in En | MEDLINE | ID: mdl-34772941
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States